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KMID : 0615720030200030166
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Jouranl of Korean Acupuncture and Moxibustion society
2003 Volume.20 No. 3 p.166 ~ p.176
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Anti-Inflammatory Effects of 15Hz Electroacupuncture on the Carrageenan-Injected Rat
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Abstract
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Objective : The aim of this study is to investigate the nati-inflammatory effects of 15Hz electroacupuncture(EA) on carrageenan-injected rats. Inflammation was induced by an intraplantar injection of 1% carrageenan into the right hind paw.
Methods : Bilateral EA stimulation with 15 Hz were delivered at those acupoints corresponding to Zusanli and Sanyinjiao in man via the needles for a total of 30 min duration in carrageenan-injected rats.
Results: The developing edema was measured 30 minutes interval afer carrageenan injection and 15 Hz EA stimulation presented significant edema inhibition. Three hours after carrageenan injection, prostaglandin E_2(PGE_2) and nitric oxide(NO) levels were measured. The 15Hz EA stimulation significantly inhibited PGE_2 and NO interleukin(IL)-1β were slightly down -regulated by EA stimulation. The number of COX-2, IL-1β, tumor necrosis factor -a immunoreactive cells were abundantly observed in paw edema. But these cells were dereased in nmber according to anti-edema effect of 15Hz EA.
Conclusions: These results indicate that 15Hz EA stimulation have an alleviation action against carrageenan induced edema and local inflammation.
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